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. 2017 Mar 28;3:11. doi: 10.1038/s41540-017-0012-5

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© The Author(s) 2017

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Fig. 6 — Relationships between levels of measured enzyme expression and model-assessed enzyme-mediated clearance. a Comparison of the specific CYP3A4-mediated clearance (CYP3A4 Cl) for midazolam, and that of CYP2C9 (CYP2C9 Cl) for torsemide, respectively, in the cohorts of 20 healthy individuals and 20 obese patients. Boxplots are defined corresponding to Fig. 2. b Correlation of specific hepatic clearance with expression levels of the indicated enzyme in all 79 diseased patients. Data are shown together with regression line and confidence interval for regression line (dashed line)