Table 3.

Parameterization of the midazolam mean value model

Molecule	Parameter	Value	Unit
Midazolam	Fraction unbound	3	%
Midazolam	Lipophilicity	3.6	[–]
Midazolam	Molecular weight	325.77	g/mol
Midazolam	Intestinal permeability	5.55E-04	cm/min
Midazolam	Solubility at reference pH	0.03	mg/ml
Midazolam	CYP3A4 kcat	0.1	1/min
Midazolam	CYP3A4 Km	2.1	µmol/l
Midazolam	ABCB1 kcat	177.64	1/min
Midazolam	ABCB1 Km	40.45	µmol/l
OH-midazolam	Fraction unbound	10	%
OH-midazolam	Lipophilicity	3.13	[–]
OH-midazolam	Molecular weight	341.8	g/mol
OH-midazolam	UGT1A4 kcat	10	1/min
OH-midazolam	UGT1A4 Km	1.41	µmol/l