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. 2017 Jun 6;7:2843. doi: 10.1038/s41598-017-02829-3

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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The expression of autophagy-related genes is upregulated in flies expressing expanded CUG or CCUG repeats in muscle or heart. Relative expression levels of Atg4, Atg7, Atg8a, Atg9 and Atg12 measured by qRT-PCR in muscle (Mhc-Gal4 driver; A) and heart samples (GMH5-Gal4 driver; B), showed a significant upregulation of these autophagy-related genes in flies expressing expanded CUG (CUG(250)×) or CCUG repeats (CCUG(1100)×). The histograms show the mean ± SEM. *p < 0.05, **p < 0.01, ***p < 0.001 (Student’s t-test).