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. 2017 Jun 6;7:2843. doi: 10.1038/s41598-017-02829-3

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Expression of expanded CUG or CCUG repeats in fly heart alters survival but not locomotion. (A) Average percentage of live flies, with the indicated genotypes, versus age (in days). The GMH5-Gal4 driver was used to induce expression of the indicated genotypes in cardiomyocytes. Horizontal dotted line marks the median survival. Flies expressing expanded CUG (CUG(250)×; n = 100) or CCUG (CCUG(1100)×; n = 97) repeats had a reduced lifespan compared to control flies (GFP; n = 100) or flies expressing the short versions of the repeats (CUG(20)×; n = 95 and CCUG(20)×; n = 99). The differences in survival curves were highly significant (p < 0.0001, log-rank test). (B) Histogram showing the climbing velocity of flies as the mean speed ± SEM in mm/s. Expression of long CUG or CCUG repeats in heart did not modify climbing velocity compared to control flies or flies expressing the short versions of repeats. (C) Notched box plot showing the median and the distribution of the average landing height data obtained in the flight assay using flies with the genotypes indicated. *p < 0.05, **p < 0.01, ***p < 0.001 (Student’s t -test).