Table 1.
Summary characteristics of the study population
| Argentina | Brazil | Colombia | Peru | Uruguay | Ecuador | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Cases | Controls | Cases | Controls | Cases | Controls | Cases | Controls | Cases | Controls | Cases | Controls | |
| N | 188 | 0 | 433 | 352 | 197 | 184 | 543 | 255 | 288 | 306 | 85 | 0 |
| AAD | 60.5 ± 13.0 | NA | 63.5 ± 12.0 | 58.8 ± 12.2 | 66.2 ± 13.2 | 53.1 ± 14.1 | 62.3 ± 11.9 | 58.2 ± 13.5 | 63.3 ± 12.4 | 60.9 ± 12.2 | 67.6 ± 10.5 | NA |
| AAO | 53.8 ± 12.9 | NA | 55.6 ± 13.1 | NA | 51.2 ± 16.5 | NA | 57.3 ± 13.0 | NA | 56.6 ± 13.1 | NA | 62.3 ± 11.8 | NA |
| % Males | 55.90% | NA | 56.7% | 24.8% | 47.1% | 46.6% | 54.5% | 29.0% | 50.3% | 35.5% | 56.0% | NA |
| % Europeana | 84.1% | 72.9% | 64.7% | 25.3% | 82.7% | NA | ||||||
| % Amerindiana | 12.8% | 7.7% | 22.4% | 68.1% | 10.9% | NA | ||||||
| G2019S (%) | 6b/185 (3.2%) | NA | 6/423 (1.4%) | 0/289 | 3/196 (1.5%) | 1/184 (0.5%) | 1c/542 (0.2%) | 1/228 (0.4%) | 12c/283 (4.2%) | 3/275 (1.1%) | 1/85 (1.2%) | NA |
| R1441G (%) | 0/181 | NA | 0/420 | 0/241 | 0/197 | 0/184 | 1/534 (0.2%) | 0/247 | 1c/270 (0.4%) | 0/265 | 0/85 | NA |
| R1441C (%) | 0/181 | NA | 1/420 (0.2%) | 0/241 | 0/197 | 0/184 | 0/534 | 0/247 | 0/270 | 0/265 | 0/85 | NA |
a Estimated average ancestry calculated using 17–50 randomly selected individuals from each site using 29 ancestry informative markers and unsupervised learning algorithm STRUCTURE
b Includes one homozygote
c 6 p.G2019S carriers and 1 p.R1441G from Peru and Uruguay were described in a previous publication [12]