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Overview of the molecular landscape of PD. The four main biological processes in the PD landscape—oxidative stress response (Fig. 1a), endosomal-lysosomal functioning (Fig. 1b), endoplasmic reticulum (ER) stress response (Fig. 1c), and neuron death and immune response (Fig. 1d)—are depicted. ECM extracellular matrix, ER endoplasmic reticulum, UPR unfolded protein response
