Table 2.
Univariate and multivariate analyses of baseline RBP4 levels.
| Variants | Univariate analysis: β (95% CI of estimated β) | Univariate analysis: p values | Multivariate analysis: β (95% CI of estimated β) | Multivariate analysis: p values |
|---|---|---|---|---|
| Sex (male) | −4.78 (−11.2–1.6) | 0.143 | ||
| Age (yr) | 0.236 (0.051–0.422) | 0.013* | 0.152 (−0.163–0.466) | 0.341 |
| BMI | −0.148 (−0.721–0.425) | 0.611 | ||
| Diabetes (yes) | 7.93 (2.29–13.57) | 0.006* | 1.78 (−5.3–0.885) | 0.618 |
| Hypertension (yes) | 8.55 (3.01–14.08) | 0.003* | 2.88 (−4.1–9.85) | 0.412 |
| Sepsis (yes) | 3.83 (−1.54–9.2) | 0.161 | ||
| Liver cirrhosis (yes) | 3.02 (−2.75–8.79) | 0.303 | ||
| Pulmonary disease (yes) | −4.32 (−6.02–5,15) | 0.879 | ||
| HOMA-IR | −0.21 (−0.69–0.26) | 0.374 | ||
| HbA1C (%) | 0.609 (−1.97–3.18) | 0.641 | ||
| C-peptide (ng/dL) | 0.492 (0.047–0.937) | 0.03* | 0.219 (0.192–0.619) | 0.292 |
| Uric acid (mg/dL) | 1.53 (0.807–2.254) | <0.001* | 0.669 (−0.368–1.706) | 0.203 |
| eGFR (mL/min/1.73 m2) | −1.34 (−0.175–0.093) | <0.001* | −0.131 (−0.196–0.065) | <0.001* |
| TC (mg/dL) | 0.16 (0.097–0.223) | <0.001* | 0.096 (0.02–0.173) | 0.014* |
| TG (mg/dL) | 0.087 (0.058–0.117) | <0.001* | 0.023 (−0.016–0.062) | 0.244 |
| HDL (mg/dL) | 0.091 (−0.224–0.406) | 0.57 | ||
| AST (U/L) | −0.002 (−0.005–0.001) | 0.217 | ||
| ALT (U/L) | −0.009 (−0.015–0.002) | 0.007* | −0.002 (−0.009–0.005) | 0.571 |
| APRI | −0.051 (−0.13–0.027) | 0.198 | ||
| Albumin (mg %) | −1.56 (−0.825–0.11) | 0.645 | ||
| Bilirubin (total) (mg %) | −0.27 (−0.53–0.009) | 0.043* | 0.007 (−0.374–0.387) | 0.972 |
| r-GT (IU/L) | 0.012 (−0.009–0.033) | 0.25 | ||
| HsCRP (mg/L) | 0.061 (0.009–0.112) | 0.022* | 0 (−0.052–0.052) | 0.991 |
| WBC (103/uL) | 0.055 (−0.197–0.306) | 0.67 | ||
| Platelets (103/uL) | 0.035 (−0.011–0.081) | 0.14 | ||
| Hb (g/dL) | −1.34 (−2.8–0.123) | 0.072 | ||
| NLR | 0.075 (−0.051–0.208) | 0.264 | ||
| PT (INR) | −8.525 (−11.288–5.762) | <0.001* | −5.05 (−9.2–0.89) | 0.018* |
RBP4: retinol-binding protein-4; BMI: body mass index; MELD: model for end-stage liver disease; APACHE: acute physiology and chronic health evaluation; ICU: intensive care unit; HOMA-IR: homeostatic model assessment for insulin resistance; TC: total cholesterol; TG: triglyceride; HDL-C: high-density lipoprotein cholesterol; AST: aspartate aminotransferase; ALT: alanine aminotransferase; APRI: aspartate aminotransferase-to-platelet ratio index; r-GT: r-glutamyltransferase; HsCRP: high-sensitivity C-reactive protein; WBC: white blood cell count; NLR: neutrophil-to-lymphocyte ratio; PT: prothrombin time; INR: international normalized ratio.