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. 2017 Jun 6;7:2876. doi: 10.1038/s41598-017-03003-5

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Delta path length of residues in dynamical network. (A) THR5, TYR85, VAL86, VAL88, TYR98 of chain A, and LEU4, VAL32, TYR85, VAL86, VAL88 of chain D have large delta path length with a Z-score greater than a cutoff value of 1.0 (light blue line). (B) The locations of the significant delta path length residues (red spheres). The chain A, chain D, and mannoses are colored in green, cyan, and magentas, respectively. The TYR98 with highest DPL is the critical residue for intermolecular network communication.