Table 3.
Ratio of expression of key genes involved in bile acid and cholesterol metabolism in the HFD+P group in relation to the HFD group.
| DUODENUM | COLON | LIVER | |
|---|---|---|---|
| FXR | 1.26 ± 1.20 | 1.78 ± 1.09 | 1.27 ± 0.25 |
| FGF15 | ND | ND | NT |
| SHP | NT | NT | 0.58 ± 0.18* |
| CYP7A1 | NT | NT | 1.84 ± 0.69* |
| HMGCR | 0.87 ± 0.72 | 2.16 ± 1.56 | 0.95 ± 0.19 |
| NPC1L1 | 0.91 ± 0.56 | 0.89 ± 0.61 | 1.37 ± 0.35 |
| ABCG5 | 1.14 ± 0.31 | 0.92 ± 0.68 | 1.03 ± 0.17 |
| ABCG8 | 1.00 ± 1.20 | 0.78 ± 0.47 | 1.23 ± 0.20p=0.067 |
| ABCA1 | 0.60 ± 0.66 | 0.75 ± 0.55 | 0.96 ± 0.31 |
Data represent the means ± SD of 6 mice per group values of p were determined using Student’s t-test where ∗ p < 0.05. Values of p compared to the HFD group are stated where appropriate. NT, not tested; ND, not detected.