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. 2017 Jun 6;7:2826. doi: 10.1038/s41598-017-02842-6

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Genes and proteins altered by hyperactivated mTOR signaling. (A) Relationships between DEGs and DEPs by hyperactivated mTOR signaling. Numbers in parentheses denote the numbers of DEGs and DEPs. (B,C) Heat maps showing up- (Up, red) and down-regulation (Down, green) of DEGs (B) and DEPs (C) between WT (1^st to 3^rd columns) and TSC1 CKO (4^th to 6^th columns) samples. The color bar represents gradients of log₂-fold-changes between TSC1 CKO and WT. Numbers in parentheses denote the numbers of up- and down-regulated genes or proteins. (D,E) GOBPs represented by up- (D) and down-regulated (E) genes (orange) or proteins (blue). The significance of GOBPs enriched by DEGs or DEPs was displayed by –log₁₀(P) where P is the enrichment P-value obtained from DAVID software. The color bar denotes gradients of –log₁₀(P). The cutoff of P-value (P = 0.05) was indicated by the dotted line.