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. 2017 Jun 6;7:2913. doi: 10.1038/s41598-017-02060-0

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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RSV CA variants generated through proteolytic cleavage of the Gag polyprotein. The figure shows the amino acid sequence of the RSV Gag polyprotein (strain Prague C) at the capsid-nucleocapsid junction with the major proteolytic cleavage sites indicated. During maturation, initial cleavage at M488 leads to the transient buildup of the species denoted CA + 12 (CA-SP)⁹². Subsequent proteolytic processing of the spacer peptide yields the species denoted CA and CA + 3, which are found in approximately 2:1 ratio in mature RSV virions⁹¹.