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. 2017 Jun 6;7:2863. doi: 10.1038/s41598-017-02671-7

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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MDA-MB-231 cells were treated with indicated concentrations of PMM-172 or Stattic for 24 h, the expression levels of STAT3 in cytoplasmic and nuclear extracts were examined and relative expression levels were analyzed by Image J software. β-actin and Lamin B1 served as markers of cytoplasmic and nuclear extractions, respectively. (A) PMM-172 suppressed STAT3 nuclear localization. (B) Stattic suppressed STAT3 nuclear localization. (C) MCF-10A cells were treated with the indicated concentrations of PMM-172 for 24 h. PMM-172 had no effect on the level of the pSTAT3 level in MCF-10A cells. (D) PMM-172 down-regulated the expression of STAT3 target genes. Data were shown as mean ± SD from three independent experiments, **P < 0.01. Cropped blots/gels were used in the figure and the gels had been run under the same experimental conditions; the full-length blots/gels are presented in Supplementary Figure S3.