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. 2017 Jun 6;7:2863. doi: 10.1038/s41598-017-02671-7

Table 2.

Anti-proliferative activity against six kinds of breast cancer cells by all compounds.

Compound IC50 (μM)
MCF-7 BT-474 SKBR-3 MDA-MB-436 MDA-MB-231 MDA-MB-468
PMM-158 12.1 ± 0.42 15.6 ± 1.03 11.5 ± 0.74 10.1 ± 0.92 9.17 ± 0.99 10.6 ± 0.65
PMM-159 9.22 ± 0.13 10.8 ± 0.94 8.95 ± 0.69 8.49 ± 0.78 7.24 ± 0.82 8.23 ± 1.27
PMM-160 15.3 ± 0.52 18.3 ± 1.24 10.5 ± 0.88 11.8 ± 0.86 9.66 ± 1.21 12.4 ± 0.52
PMM-161 9.81 ± 0.49 11.1 ± 1.12 9.29 ± 0.66 9.55 ± 0.83 8.58 ± 0.53 8.97 ± 1.05
PMM-162 9.01 ± 0.92 9.54 ± 0.91 8.03 ± 0.83 7.28 ± 0.77 6.14 ± 1.05 6.85 ± 0.92
PMM-163 8.69 ± 0.83 9.27 ± 0.86 7.56 ± 0.72 7.09 ± 0.63 6.04 ± 0.59 7.83 ± 0.55
PMM-164 5.71 ± 0.52 7.09 ± 0.65 4.49 ± 0.58 4.41 ± 0.55 3.76 ± 1.02 3.94 ± 0.73
PMM-165 9.38 ± 0.66 9.22 ± 0.98 6.23 ± 0.73 5.97 ± 0.67 5.47 ± 1.01 6.58 ± 0.15
PMM-166 6.41 ± 0.75 6.91 ± 0.73 4.87 ± 0.58 4.66 ± 0.59 3.64 ± 0.91 4.07 ± 0.66
PMM-167 15.3 ± 0.61 13.7 ± 0.92 9.76 ± 0.95 10.6 ± 0.82 9.01 ± 0.56 12.2 ± 0.42
PMM-168 9.27 ± 1.12 10.6 ± 0.81 8.16 ± 0.71 7.87 ± 0.91 6.09 ± 1.04 8.42 ± 0.86
PMM-169 8.12 ± 0.98 8.36 ± 0.97 6.95 ± 0.82 7.36 ± 0.87 5.33 ± 0.77 7.22 ± 1.11
PMM-170 9.73 ± 1.03 12.7 ± 1.06 8.27 ± 0.69 6.88 ± 0.73 4.31 ± 0.65 8.44 ± 0.78
PMM-171 8.71 ± 0.67 8.59 ± 0.78 5.89 ± 0.64 6.49 ± 0.68 3.14 ± 1.02 6.95 ± 0.46
PMM-172 4.87 ± 0.55 5.26 ± 0.66 3.14 ± 0.46 3.07 ± 0.47 1.98 ± 0.49 3.24 ± 0.27
PMM-173 5.58 ± 0.83 6.03 ± 0.71 3.59 ± 0.49 4.06 ± 0.53 2.59 ± 0.19 3.76 ± 0.88
Shikonin 4.57 ± 0.69 5.74 ± 0.66 3.75 ± 0.52 3.28 ± 0.41 2.88 ± 0.25 3.61 ± 0.34
Stattic 5.85 ± 0.72 5.11 ± 0.57 3.39 ± 0.56 3.76 ± 0.50 3.18 ± 0.33 3.54 ± 0.42