Fig. 2.

Sacubitril/Valsartan’s MoA. Every relationship depicted represents a mechanism by which the drug could directly or indirectly (via downstream effectors) improve or reverse pathological cardiac remodeling, either through the activation (green arrows) or inhibition (red arrows) of downstream proteins. The same synergistic MoA was identified for both, MI and HF, cohorts; therefore, the depiction applies for both of them. Gray dotted-line circles encompass the proteins affected either by Sacubitril, Valsartan, or both. Blue dotted-line circle encompass the core of eight proteins that the mathematical models predict to act synergistically, by being related to both, Sacubitril and Valsartan, pathways in some manner