Reference data and CAD detections for two cases. (a)–(c) Case 1: a 40-year-old male, with primarily sclerotic lesions; (d)–(f) case 2: a 61-year-old male, with primarily lytic and mixed lesions. (a) and (d) 3-D rendering of reference lesions superimposed on the segmented spine column, green: sclerotic, blue: lytic, red: mixed lesions; (b) and (e) CAD detections before classification, and (c) and (f) CAD detections after classification. Green: true positive detections and blue: false positive detections. True positives are determined by the overlap with the reference lesion segmentation.