Table 1.
Baseline characteristics of the 31 patients
| Demographics | Baseline | Follow-up |
|---|---|---|
| Male, n | 19 (61%) | |
| Mean age + −SD, years 70.2 (SD 11.7) | ||
| < 9 years of education | 5 (16%) | |
| Stroke subtype | ||
| Cerebral infarction | 29 (94%) | |
| TIA | 2 (6%) | |
| Risk factors, n | ||
| Hypertension | 20 (65%) | |
| Hyperlipideamia | 23 (74%) | |
| Diabetes | 6 (19%) | |
| Current smoking | 7 (23%) | |
| Atrial fibrillation | 3 (10%) | |
| BMI | 18 (58%) | |
| TOAST classification, n | ||
| Large-vessel disease | 2 (7%) | |
| Cardio-embolic disease | 2 (6%) | |
| Small vessel disease | 17 (55%) | |
| Stroke of undetermined aetiology | 10 (32%) | |
| OCSP classification, n | ||
| TACI | 0 | |
| PACI | 13 (42%) | |
| LACI | 15 (48%) | |
| POCI | 3 (10%) | |
| Assessments | ||
| NIHSS, day 1, mean (IQR) | 3.06 (1.0-4.0) | 0.58 (0.0-1.0) |
| BI, mean(IQR) | 18.5 (19.5-20.0) | 19.48 (20.0-20.0) |
| mRS, mean (IQR) | 1.35 (0.0-3.0) | 1.06 (1.0-1.0) |
| Total TAU, mean (IQR) | 363 (227–382) | |
| Apoɛ4 | 9 (29%) | |
| TMT A (seconds) (SD) | 86.0 (±97.0) | 61.6 (±48.4) |
| MMSE (points) (SD) | 26.0 (±3.8) | 26.7 (±3.9) |
| 10 word test (words) | 20.1 (±6.8) | 24.5 (±6.1) |
| Ventricular volume (mm^3)(SD) | 60,796 (±17,339) | 60,334 (±25,118) |
| Global brain volume(mm^3) (SD) | 1,404,660 (±63,160) | 1,368,194 (±142,856) |
TIA = Transient Ischemic Attack; Hyperlipidemia = total cholesterol >5 mmol/l or LDL-cholesterol >3 mmol/l; LDL = Low Density Lipoprotein; BMI = body mass index; TOAST = The Trial of Org 10,172 in Acute Stroke Treatment classification; OCSP = Oxfordshire Community Stroke Project classification; TACI = Total Anterior Circulation Infarction; PACI = Partial Anterior Circulation Infarction; LACI = Lacunar Circulation Infarction; POCI = Posterior Circulation Infarction; NIHSS = National Institute of Health Stroke Scale; IQR = Interquartile range; BI = Barthel Activities of Daily Living Index; mRs = modified Rankin scale; Apoɛ4 = apo lipoprotein E allel 4; TMT A = trail making test A; SD = standard deviation); MMSE = mini metal test examination