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. 2017 Jun 6;5:17016. doi: 10.1038/boneres.2017.16

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Copyright © 2017 The Author(s)

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Forced expression of SOST does not modify bone diameters in Bmpr1a-deficient mice. (a) Mating scheme. (b) X-ray radiography of the hindlimb from littermate mice at P33. Arrows denote restricted region in the proximal femur specific to CKO and SOST;CKO mice. Lines indicate expanded cancellous bone region. (c and d) μCT images (c) or quantification (d) of cortical bone acquired at the regions marked by the arrows or the equivalent regions in (b). *P<0.001, one-way ANOVA, n=5 for CTRL and CKO, n=6 for SOST, n=7 for SOST;CKO. f, femur; fi, fibula; SOST, sclerostin; t, tibia; μCT, micro-computed tomography.