Fig. 2.

Comparison of the performance of all Standard Search Matrices with the novel PFASUM Search Matrices on three different ASTRAL datasets. The highest achieved coverage at 0.01 errors per query for any gap opening and extension penalty combination is shown (parameters are listed in Additional file 8: Table S4). With the exception of two performance differences, all shown coverage values are significantly different according to our Z-score analysis shown in Additional file 9: Table S5