Table 4.
Pharmacokinetic parameters of 20(R)-Rh1, 20(S)-Rh1, 20(R)-Rg3, and 20(S)-Rg3 in male rats after oral administration of SMS and Radix Ginseng Rubra extracts (1.35 mL/100 g).
| Herb extract | Pharmacokinetic parameters | Ginsenosides | |||
|---|---|---|---|---|---|
| 20(R)-Rh1 | 20(S)-Rh1 | 20(R)-Rg3 | 20(S)-Rg3 | ||
| SMS | T max (h) | 0.0833 | 1.50 | 1.50 | 1.50 |
| C max (ng/mL) | 114.34 ± 26.51 | 195.34 ± 44.91 | 63.26 ± 16.99∗∗ | 124.43 ± 15.82∗∗ | |
| t 1/2 (h) | 3.69 ± 0.87 | 4.21 ± 1.05∗ | 4.45 ± 0.98 | 6.38 ± 1.72∗ | |
| AUC(0–t) (ng/mL) | 352.11 ± 40.70∗∗∗ | 409.48 ± 62.23∗∗ | 138.41 ± 13.56∗∗∗ | 293.74 ± 20.93∗∗∗ | |
| AUC(0–∞) (ng/mL) | 377.75 ± 46.32∗∗∗ | 419.75 ± 65.31∗∗ | 163.60 ± 18.38∗∗∗ | 319.30 ± 22.66∗∗∗ | |
| AUCC | 271.76 ± 33.12∗∗∗ | 677.02 ± 105.34∗∗ | 53.82 ± 6.05∗∗ | 212.87 ± 15.10∗∗∗ | |
|
| |||||
| Radix Ginseng Rubra | T max (h) | 0.50 | 0.50 | 0.50 | 0.50 |
| C max (ng/mL) | 80.94 ± 19.53 | 152.49 ± 30.98 | 32.82 ± 10.65 | 53.44 ± 20.03 | |
| t 1/2 (h) | 2.94 ± 0.76 | 2.85 ± 0.69 | 3.70 ± 0.43 | 4.14 ± 1.18 | |
| AUC(0–t) (ng/mL) | 85.92 ± 16.52 | 157.53 ± 25.46 | 28.98 ± 3.77 | 92.45 ± 10.58 | |
| AUC(0–∞) (ng/mL) | 86.96 ± 16.89 | 159.27 ± 26.03 | 29.54 ± 4.19 | 95.06 ± 10.99 | |
| AUCC | 86.90 ± 16.89 | 159.20 ± 26.03 | 29.50 ± 4.19 | 95.00 ± 10.99 | |
Mean ± SD. ∗P < 0.05, ∗∗P < 0.01, ∗∗∗P < 0.001 compared with those from Radix Ginseng Rubra extract.