Table 1.
Functions of overall differentially expressed genes
| Set | Collection | # genes | r_rb | SE(r_rb) |
|---|---|---|---|---|
| chr17q11 | C1:All | 66 | 0.88 | 0.021 |
| chr12q13 | C1:All | 152 | 0.84 | 0.026 |
| NIKOLSKY BREAST CANCER 17Q11 Q21 AMPLICON | C2:CGP | 80 | 0.84 | 0.033 |
| chr17q21 | C1:All | 164 | 0.69 | 0.033 |
| chr4q21 | C1:All | 61 | 0.62 | 0.066 |
| chr1p13 | C1:All | 79 | 0.59 | 0.06 |
| GNF2 DNM1 | C4:CGN | 63 | 0.41 | 0.046 |
| RICKMAN HEAD AND NECK CANCER A | C2:CGP | 77 | 0.34 | 0.06 |
| LEIN NEURON MARKERS | C2:CGP | 50 | 0.34 | 0.052 |
| CAHOY NEURONAL | C6:All | 84 | 0.33 | 0.053 |
| GCM MAP1B | C4:CGN | 53 | 0.33 | 0.076 |
| ANASTASSIOU CANCER MESENCHYMAL TRANSITION SIGNATURE | C2:CGP | 53 | 0.33 | 0.069 |
| SABATES COLORECTAL ADENOMA UP | C2:CGP | 86 | 0.33 | 0.049 |
| GNF2 CCNA2 | C4:CGN | 52 | 0.32 | 0.065 |
| KRAS.KIDNEY UP.V1 UP | C6:All | 113 | 0.32 | 0.047 |
| VOLTAGE GATED CATION CHANNEL ACTIVITY | C5:MF | 57 | 0.31 | 0.061 |
| NAKAYAMA SOFT TISSUE TUMORS PCA2 UP | C2:CGP | 71 | 0.31 | 0.053 |
| GCM MAPK10 | C4:CGN | 71 | 0.31 | 0.059 |
| CERVERA SDHB TARGETS 1 UP | C2:CGP | 95 | 0.3 | 0.052 |
| VOLTAGE GATED CHANNEL ACTIVITY | C5:MF | 63 | 0.3 | 0.058 |
The 20 (of 5247) MSigDB gene sets most enriched with genes scoring high for overall differential expression between humans and chimpanzees are listed. Collection is the MSigDB collection containing the set (one of 16). genes is the number of genes whose expression we measured in the set (at least 50). r rb is the rank-biserial correlation between scores for differential expression and membership in the set; sets are ordered by decreasing r rb. SE(r rb) is the standard error of r rb via bootstrapping with 10,000 replicates