Fig. 5.

Pharmacological inhibition of PDE3A and CAA-associated spontaneous CMH development. Significant increase in Prussian blue (PB)-positive CMH number (a), size (b), and area (c) in the Tg mice compared with the WT mice. No significant effect of PDE3A inhibition by cilostazol on any of these CMH parameters. Representative images of PB-positive lesions (indicated by arrows) in WT and Tg mice with or without cilostazol treatment (d). Data are presented as mean ± SEM. Statistical test: one-way ANOVA with Bonferroni’s post-test or Kruskal-Wallis test with Dunn’s post-test. *p < 0.05, **p < 0.01