Table 10.
In vitro selections using INSTI resistant viruses
| Starting genotype | Drug selection | Genotype (week) | References |
|---|---|---|---|
| E92Q | DTG | E92Q (8), E92Q/R263K (30) | [52, 57] |
| E92Q | RAL | E92Q, L74M/E92Q (8) | [52] |
| E92Q | EVG | E92Q (8) | [52] |
| E138K | RAL | T66I/T97A/E138K/P142T/G163R (30) | [88] |
| E138K | EVG | G70R/E138K/N155H/V249I/R263K (30) | [88] |
| Y143C | RAL | Y143R, Y143R/G163R, E92Q/Y143R, G163R/E170A (8) | [52] |
| Y143R | DTG | Y143R (8) | [52] |
| Y143R | RAL | Y143R, L74M/Y143R, Y143R/N155H (8) | [52] |
| Q148K | DTG | E138K/Q148K (8) | [52] |
| Q148K | RAL | Q148K, E138K/Q148K (8) | [52] |
| Q148K | EVG | Q148K, E138K/Q148K (8) | [52] |
| Q148R | DTG | ND (30) | [57] |
| Q148R | DTG | G140S/Q148R, G140S/Q148R/V201I, E138K/G140S/Q148R (8) | [52] |
| Q148R | RAL | Q148R, G140S/Q148R, G140S/Q148R/V259I, L74M/G140S/Q148R (8) | [52] |
| Q148R | EVG | Q148R, E138K/Q148R (8) | [52] |
| Q148H | DTG | G140S/Q148H, T97A/G140S/Q148H, V75I/E138K/G140S/Q148H/M154I (8) | [52] |
| Q148H | RAL | G140S/Q148H | [52] |
| Q148H | EVG | G140S/Q148H | [52] |
| G140S | DTG | V131I/V54I/Q148R/G140S (30) | [57] |
| N155H | DTG | N155H (8), N155H/R263K (30) | [52, 57] |
| N155H | RAL | N155H, G70R/N155H, N155H/G163R/D232N, S119R/N155H, P142T/N155H/G163R (8) | [52] |
| N155H | EVG | N155H, N155H/S230K, N155H/D232N, N155H/E170K, G70R/V75I/N155H (8) | [52] |
| R263K | RAL | R263K (30) | [88] |
| R263K | EVG | M50I/T66I/R263K (30) | [88] |
| G118R | DTG | T66I/G118R/E138K (25) | |
| G118R | RAL | T66I/G118R/E138K (30) | [88] |
| G118R | EVG | T66I/G118R/E157Q (30) | [88] |
| H51Y | DTG | H51Y/R262K (25) | [89] |
| H51Y | RAL | H51Y/G140S/Q148R (30) | [88] |
| H51Y | EVG | H51Y/T66I/S147G/G163R/E170K/D232N (30) | [88] |
| G140S/Q148R | DTG | K14R/H51Y/V54I/G140S/Q148R (30) | [57] |
| E92Q/N155H | DTG | E92Q/N155H (30) | [57] |
| E138K/R263K | RAL | H51N/T66I/T97A/S119R/E138K/Y143H/R263K (30) | [88] |
| E138K/R263K | EVG | M50I/T66I/S119R/E138K/S147G/R263K (30) | [88] |
| H51Y/G118R | DTG | H51Y/G118R (25) | [89] |
| H51Y/G118R | RAL | H51Y/T66I/G118R (30) | [88] |
| H51Y/G118R | EVG | H51Y/T66I/S147G/H171R/D232N (30) | [88] |
| H51Y/R263K | DTG | H51Y/E138K/R263K (25) | [89] |
| H51Y/R263K | RAL | E138K/Y143R/R263K (30) | [88] |
| H51Y/R263K | EVG | V31I/H51Y/E92Q/R263K (30) | [88] |
Substitutions that differ between baseline and final selection are in italics. Numbers refer to amino acid position in HIV integrase, one letter amino acid code used. Raltegravir (RAL), elvitegravir (EVG), dolutegravir (DTG), no change detectable (ND)