Table 2.
In vitro and in vivo selection of de novo exclusively raltegravir-associated resistance substitutions in HIV IN in tissue culture and in INSTI-naïve individuals
| Substitutions | RAL | |
|---|---|---|
| Selection | In vitro | In vivo |
| Y143 | ||
| Y143C | X | X |
| L74M/T97A/Y143R/G163R | X | |
| T97A/Y143C/G163R | X | |
| Q95K/Y143C | X | |
| L74M/T97A/E138D/Y143R/G163N | X | |
| T97A/Y143C | X | |
| Y143C/S230R | X | |
| L74M/T97A/Y143G | X | |
| Y143H | X | X |
| Y143K | X | |
| T97A/Y143S | X | |
| T97A/E138A/Y143K | X | |
| Y143S/V201I | X | |
| Y143R | X | X |
| V72I/Y143R/T206S | X | |
| L74M/T97A/Y143R | X | |
| L74M/T97A/E138A/Y143R | X | |
| T97A/Y143R | X | |
| Y143R/D232N | X | |
| G140S/Y143R | X | |