Table 6.
Levels of in vitro resistance for HIV-1 INSTI mutated viruses with raltegravir resistance pathways
| Genotype | RAL | EVG | DTG | CTG | BIC |
|---|---|---|---|---|---|
| Y143 | |||||
| Y143C | + | − | − | − | − |
| L68V/Y143C | ++ | − | − | NA | − |
| L68V/L74M/Y143C | +++ | ++ | − | NA | − |
| L74M/T97A/E138A/Y143C | ++ | NA | − | NA | |
| Q95K/Y143C | + | − | NA | NA | NA |
| T97A/Y143C | +++ | + | − | NA | − |
| T97A/Y143C/G163R | ++ | + | NA | NA | NA |
| L74M/T97A/Y143G | ++ | NA | − | NA | NA |
| Y143H | − | − | − | − | NA |
| Y143K | + | NA | NA | NA | NA |
| T97A/E138A/Y143K | ++ | NA | NA | NA | NA |
| T97A/Y143S | + | NA | NA | NA | NA |
| Y143S/V201I | + | NA | NA | NA | NA |
| Y143R | ++ | + | − | − | − |
| V72I/Y143R/T206S | ++ | NA | NA | NA | NA |
| T97A/Y143R | +++ | ++ | − | NA | − |
| L74M/T97A/Y143R | NA | NA | − | NA | NA |
| L74M/T97A/E138A/Y143R | ++ | − | NA | NA | |
| L74M/T97A/E138D/Y143R/G163N | +++ | ++ | NA | NA | |
| G140S/Y143R | ++ | NA | NA | NA | NA |
Scale: ‘−’ no fold-change (FC), ‘+’ low FC, ‘++’ moderate FC, and ‘+++’ high FC from measured WT 50% inhibitory concentration (EC50). NA denotes no value available. Numbers refer to amino acid position in HIV integrase, one letter amino acid code used
References: [14, 16, 28, 29, 31, 32, 36, 40, 43–45, 49–52, 54–69]