Table 7.
Levels of in vitro resistance for HIV-1 INSTI mutated viruses with pan-INSTI resistance pathways
| Genotype | RAL | EVG | DTG | CTG | BIC |
|---|---|---|---|---|---|
| Q148 | |||||
| Q148H | + | + | − | − | NA |
| G140S/Q148H | +++ | +++ | + | + | + |
| E138K/Q148H | ++ | ++ | − | − | NA |
| L74M/T97A/G140S/Q148H | NA | NA | ++ | NA | NA |
| L74M/E138A/G140S/Q148H | NA | NA | ++ | NA | NA |
| T97A/E138K/G140S/Q148H/N155H | NA | NA | +++ | NA | NA |
| T97A/T112S/G140S/Q148H | +++ | NA | + | NA | NA |
| T97A/T112S/G140S/Q148H/N155H | +++ | NA | +++ | NA | NA |
| E92Q/T97A/G140S/Q148H | NA | NA | ++ | NA | NA |
| E138K/G140S/Q148H/N155H | NA | NA | ++ | NA | NA |
| T97A/G140S/Q148H | +++ | +++ | ++ | NA | + |
| E138A/G140S/Q148H | +++ | +++ | ++ | NA | ++ |
| E138A/G140S/Y143H/Q148H | +++ | ++ | NA | NA | |
| E138K/G140S/Q148H | +++ | +++ | ++ | NA | + |
| E138K/G140S/Q148H/M154I | +++ | +++ | + | NA | NA |
| V75I/E138K/G140S/Q148H/M154I | +++ | +++ | + | NA | NA |
| G140S/Y143H/Q148H | NA | NA | + | NA | NA |
| G140S/Q148H/N155H | +++ | NA | NA | NA | NA |
| T112S/G140S/Q148H/G163K | +++ | NA | NA | NA | NA |
| G140S/Q148H/G163K | +++ | +++ | + | NA | − |
| Q148K | +++ | +++ | − | + | NA |
| G140S/Q148K | + | +++ | − | + | NA |
| E138K/Q148K | +++ | +++ | ++ | +++ | + |
| E138K/G140A/Q148K | +++ | +++ | +++ | NA | +++ |
| Q148N | − | + | − | NA | NA |
| G140S/Q148N | − | + | − | NA | NA |
| Q148R | ++ | +++ | − | NA | − |
| T66I/Q148R | ++ | +++ | + | NA | NA |
| E92Q/Q148R | +++ | +++ | + | NA | NA |
| G140S/Q148R | +++ | +++ | + | + | + |
| G140S/Q148R/V201I | +++ | +++ | + | NA | NA |
| G140C/Q148R | +++ | +++ | + | ++ | − |
| G140A/Q148R | +++ | +++ | − | NA | − |
| G140A/Q148R/G163R | ++ | NA | NA | NA | NA |
| E138K/Q148R | +++ | +++ | + | ++ | − |
| E138K/G140S/Q148R | +++ | +++ | + | NA | NA |
| E138A/Q148R | ++ | ++ | + | ++ | − |
| N155H/Q148R | +++ | +++ | + | NA | + |
| L74I/G140S/Q148R | +++ | +++ | NA | NA | NA |
| L74M/G140A/Q148R | +++ | +++ | ++ | NA | + |
| L74M/G140C/Q148R | +++ | +++ | ++ | NA | ++ |
| E138A/S147G/Q148R | ++ | +++ | − | + | NA |
| E138K/G140C/Q148R | +++ | +++ | ++ | NA | + |
| N155 | |||||
| N155H | ++ | ++ | − | − | − |
| T66I/N155H | ++ | +++ | NA | NA | NA |
| V72I/N155H | ++ | NA | NA | NA | NA |
| L74M/N155H | ++ | ++ | − | + | − |
| L74M/V151I/N155H | ++ | ++ | NA | NA | NA |
| L74M/T97A/Y143R/N155H | NA | NA | + | NA | NA |
| L74M/N155H/R263K | + | +++ | + | NA | NA |
| L74M/T97A/E138A/Y143R/N155H | NA | NA | + | NA | NA |
| E92Q/N155H | +++ | +++ | + | + | + |
| E92Q/V151I/N155H | ++ | ++ | NA | NA | NA |
| E92Q/N155H/G163R | +++ | +++ | ++ | NA | + |
| E92Q/N155H/R263K | ++ | +++ | + | NA | NA |
| Q95K/N155H | + | ++ | NA | NA | NA |
| T97A/N155H | ++ | ++ | − | + | − |
| T97A/V151I/N155H | +++ | NA | NA | NA | NA |
| T97A/V125A/V151I/N155H | +++ | NA | NA | NA | NA |
| T97A/N155H/R263K | + | +++ | + | NA | NA |
| S119R/S147G/V151I/N155H | ++ | ++ | − | NA | NA |
| S119R/T97A/E138K/S147G/V151I/N155H | +++ | +++ | ++ | NA | NA |
| V125A/V151I/N155H | ++ | NA | NA | NA | NA |
| E138D/N155H | + | ++ | NA | NA | NA |
| Y143H/N155H | ++ | ++ | − | + | NA |
| V151I/N155H | NA | NA | NA | NA | NA |
| E157Q/N155H | NA | NA | NA | NA | NA |
| N155H/E157Q/R263K | + | +++ | + | NA | NA |
| N155H/G163K | ++ | ++ | − | − | NA |
| N155H/G163R | ++ | ++ | − | − | − |
| N155H/G163R/R263K | + | +++ | + | NA | NA |
| N155H/D232N | ++ | ++ | − | + | NA |
| N155H/R263K | + | + | + | NA | NA |
| N155S | + | ++ | − | − | NA |
| N155T | + | ++ | − | − | NA |
Scale: ‘−’ no fold-change (FC), ‘+’ low FC, ‘++’ moderate FC, and ‘+++’ high FC from measured WT 50% inhibitory concentration (EC50). NA denotes no value available. Numbers refer to amino acid position in HIV integrase, one letter amino acid code used
References: [14, 16, 28, 29, 31, 32, 36, 40, 43–45, 49–52, 54–69]