Table 4.

Parameter estimates for paths in final structural equation model (fig 6), with their bias corrected 95% confidence intervals and P values, in 511 participants

Path		Change in y for each unit increase in x (95% CI)	P value
From (x)	To (y)
Average alcohol*	Hippocampal volume	−0.572 (−0.800 to −0.353)	0.01
Average alcohol	Corpus callosum mean diffusivity†	0.038 (0.017 to 0.064)	0.009
Average alcohol*	Lexical fluency decline	−0.002 (−0.005 to 0.000)	0.08
Corpus callosum mean diffusivity†	Lexical fluency decline	−0.011 (−0.022 to −0.003)	0.003
Age	Hippocampal volume	−0.020 (−0.021 to −0.013)	0.008
Age	Corpus callosum mean diffusivity2	0.003 (0.002 to 0.003)	0.03

*As fraction of 100 units weekly.

†As multiplicative of 1000.