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. Author manuscript; available in PMC: 2018 Jul 1.
Published in final edited form as: Neurobiol Aging. 2017 Apr 8;55:213–216. doi: 10.1016/j.neurobiolaging.2017.03.032

Fig. 1.

Fig. 1

Effect CR on circulating 24-h melatonin patterns in young and old rhesus macaques. Left panels: Mean plasma 24-h melatonin profiles from (A) young control (n=5) and old control (n=6) males; (B) young control (n=5) and young CR (n=5) males; (C) old control (n=6) and old CR (n=4) males; (D) young control (n=5) and old CR (n=4) males; (E) young control (n=4) and old control (n=7) females; (F) young control (n=4) and young CR (n=4) females; (G) old control (n=7) and old CR (n=5) females; (H) young control (n=4) and old CR (n=5) females. The horizontal black and white bar on the abscissas correspond to the 12 h light:12 h dark lighting schedule. Right panels: Analyses of age, CR and age in combination with CR-related differences in the mean 24-h area under the curve (AUC) of melatonin concentrations. Data are expressed as mean ± SEM. *p < 0.05, ***p < 0.001 (Newman Keuls test).