Table 1.

CMF studies carried out at the Istituto Nazionale Tumori in Milan

Enrolment period	Study design	Eligible patients	Intervention	No of patients
June 1973 to September 1975	Randomised controlled trial	Node positive, premenopausal, and postmenopausal	Surgery v CMF for 12 cycles	179 v 207
September 1975 to May 1978	Randomised controlled trial	Node positive, premenopausal	CMF for 12 cycles v CMF for 6 cycles	160 v 164
May 1978 to October 1980	Observational study	Node positive, premenopausal	CMF for 12 cycles	220
December 1980 to October 1985	Randomised controlled trial	Node negative and oestrogen receptor negative, premenopausal, and postmenopausal	Surgery v intravenous CMF for 12 cycles	45 v 45