Skip to main content
. Author manuscript; available in PMC: 2018 Apr 25.
Published in final edited form as: Circulation. 2017 Apr 25;135(17):1671–1673. doi: 10.1161/CIRCULATIONAHA.116.025338

Figure 1. Oral choline supplementation increases fasting TMAO levels, enhances platelet aggregation, and attenuates the anti-platelet effect observed with aspirin.

Figure 1

A) Plasma TMAO levels and platelet aggregation in response to submaximal (5μM) ADP in vegan/vegetarian and omnivore groups. B) Correlation between plasma TMAO and platelet aggregation responses amongst the indicated groups. Spearman correlations and p values shown. C) Effect of choline supplementation on TMAO and platelet aggregation responses in omnivores in the absence versus presence of aspirin (ASA). All data shown are mean (±SEM) with the indicated number of subjects. Asterisks shown represent p<0.05 for comparison of aggregation responses off versus on ASA for the corresponding time point. P values were calculated with Wilcoxon Rank Sum test for two-group comparisons, and Wilcoxon Signed Rank Test for pairwise comparisons.