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. Author manuscript; available in PMC: 2018 Apr 18.
Published in final edited form as: Chem Soc Rev. 2017 Apr 18;46(8):2158–2198. doi: 10.1039/c6cs00765a

Fig 19.

Fig 19

Optoacoustic imaging of pharmacokinetics and bio-distribution. (a) Images of a subcutaneous 4T1 breast tumour in a mouse obtained with 4D optoacoustic tomography after injection of liposomal indocyanine green (Lipo-ICG). The corresponding temporal profiles for the three marked regions of interest are shown in (b). Adapted with permission from [312]. © 2015 European Society of Radiology with permission of Springer. (c) MSOT imaging of bio-distribution of a 1,1’-dioctadecyltetramethyl indotricarbocyanine iodide (DiR)-loaded polyethyleneimine functionalized poly(lactic-coglycolic acid) (PEI-PLGA) nanoparticles in a CD1 mouse. Green colour scale corresponds to the unmixed distribution of the probe. Adapted with permission from [313]. © 2015 John Wiley & Sons.