Table 2.

The effect of the protein dielectric constant on absolute (ΔG) and relative (ΔΔG) binding affinities. See TABLE 1 for additional information. RMSD values are given in kcal/mol. The raw data used to generate these results is available in Supporting Information (Table S2).

	MG Corrected					No MG Correction
EPSIN	RMSD	RMSD(ΔΔG)	Slope	p-value	R	RMSD	RMSD(ΔΔG)	Slope	p-value	R
1	87	110	25	0.67	0.15	120	160	39	0.64	0.17
2	53	60	20	0.53	0.22	78	89	27	0.56	0.21
4	37	34	15	0.41	0.30	50	50	19	0.47	0.26
6	31	24	13	0.32	0.35	40	36	16	0.40	0.30
8	27	19	11	0.25	0.40	35	28	14	0.35	0.33
12	23	12	9.6	0.13	0.51	29	19	11	0.25	0.40
16	22	10	8.5	7.9E-02	0.58	26	15	10	0.19	0.45
20	19	6	8.1	6.7E-03	0.79	23	10	9.6	6.1E-02	0.61
24	20	7	7.4	2.1E-02	0.71	23	11	8.7	0.10	0.55