Table 4.
Association of measures of adiposity with kidney function decline using eGFRcr
| Variable | N | ΔeGFR-Cr>30% | Unadjusted OR (95% CI) | Model 1a OR (95% CI) | Model 2b OR (95% CI) |
|---|---|---|---|---|---|
| Subcutaneous fat | |||||
| Continuous (per SD=121) | 1219 | 339 | 1.2 (1.1 to 1.4) | 1.2 (1.0 to 1.4) | 1.1 (0.9 to 1.3) |
| Quartiles | |||||
| <196 | 295 | 72 | 1.0 (ref) | 1.0 (ref) | 1.0 (ref) |
| 196–267 | 301 | 71 | 1.0 (0.7 to 1.4) | 1.0 (0.7 to 14) | 0.9 (0.6 to 1.3) |
| 268–357 | 322 | 92 | 1.2 (0.9 to 1.8) | 1.2 (0.8 to 1.7) | 1.0 (0.7 to 1.5) |
| >357 | 301 | 104 | 1.6 (1. 1 to 2.3) | 1.5 (1.0 to 2. 2) | 1.2 (0.8 to 1.9) |
| Visceral fat | |||||
| Continuous (per SD=67) | 1219 | 339 | 1.2 (1.0 to 1.3) | 1.2 (1.2 to 1.4) | 1.1 (0.9 to 1.3) |
| Quartiles | |||||
| <94 | 296 | 69 | 1.0 (ref) | 1.0 (ref) | 1.0 (ref) |
| 94–132 | 312 | 82 | 1.2 (0.9 to 1.8) | 1.3 (0.9 to 1.9) | 1.2 (0.8 to 1.8) |
| 133–181 | 315 | 96 | 1.6 (1.1 to 2.2) | 1.3 (1.2 to 2.4) | 1.4 (1.0 to 2.1) |
| >181 | 296 | 93 | 1.7 (1.2 to 2.5) | 1.8 (1.2 to 2.7) | 1.4 (0.9 to 2.1) |
| R thigh intermuscular fat area, cm2 | |||||
| Continuous (per SD=6.8) | 1215 | 337 | 1.2 (1.0 to 1.4) | 1.1 (1.0 to 1.3) | 1.0 (0.9 to 1.2) |
| Quartiles | |||||
| <6.15 | 329 | 84 | 1.0 (ref) | 1.0 (ref) | 1.0 (ref) |
| 6.15–9.01 | 332 | 81 | 0.9 (0.7 to 1.3) | 0.9 (0.6 to 1.3) | 0.8 (0.6 to 1.2) |
| 9.02–13.12 | 297 | 96 | 1.4 (1.0 to 2.0) | 1.3 (0.3 to 1.9) | 1.1 (0.8 to 1.6) |
| >13.12 | 257 | 76 | 1.2 (0.8 to 1.7) | 1.1 (0.7 to 1.6) | 0.8 (0.6 to 1.3) |
| Waist circumference | |||||
| Continuous (per SD=12.5) | 1219 | 339 | 1.2 (1.1 to 1.4) | 1.2 (1.1 to 1.4) | 1.1 (1.0 to 1.3) |
| Quartiles | |||||
| <91.7 | 306 | 77 | 1.0 (ref) | 1.0 (ref) | 1.0 (ref) |
| 91.7–99.2 | 328 | 77 | 0.9 (0.7 to 1.4) | 1.0 (0.7 to 1.4) | 0.9 (0.6 to 1.4) |
| 99.3–107.1 | 311 | 93 | 1.3 (0.9 to 1.8) | 1.3 (0.9 to 1.9) | 1.2 (0.8 to 1.8) |
| >107.1 | 274 | 92 | 1.5 (1.2 to 2. 2) | 1.5 (1.0 to 2.2) | 1.2 (0.8 to 1.8) |
| BMI | |||||
| Continuous (per SD=4.6) | 1219 | 339 | 1.2 (1.1 to 1.4) | 1.2 (1.1 to 1.4) | 1.1 (0.9 to 1.3) |
| Quartiles | |||||
| <24.1 | 292 | 68 | 1.0 (ref) | 1.0 (ref) | 1.0 (ref) |
| 24.1–26.8 | 329 | 78 | 1.1 (0.7 to 1.6) | 1.2 (0.8 to 1.7) | 1.1 (0.7 to 1.6) |
| 26.9–30.0 | 324 | 97 | 1.5 (1.0 to 2.2) | 1.6 (1.2 to 2.4) | 1.5 (1.0 to 2.2) |
| >30.1 | 274 | 96 | 1.8 (1.2 to 2.6) | 1.9 (1.3 to 2.8) | 1.5 (1.0 to 2.3) |
OR, odds ratio; 95% CI, 95% confidence interval; ref, reference; R, right; BMI, body mass index.
a
Adjusted for age, sex, race, and site.
b
Further adjusted for diabetes mellitus, systolic blood pressure, hypertension meds, albumin-to-creatinine ratio, smoking, LDL cholesterol, HDL cholesterol, oral estrogen, prevalent coronary heart disease, prevalent heart failure, and C-reactive protein. Kidney function decline was defined as eGFR-Cr decline >30% (using creatinine at years 3 and 10).