Table 5.
Association of measures of adiposity with incident CKD
| Variable | N | Inc CKD | Rate (%/yr) | Unadjusted IRR (95% CI) | Model 1a IRR (95% CI) | Model 2b IRR (95% CI) |
|---|---|---|---|---|---|---|
| Subcutaneous fat | ||||||
| Continuous (per SD=121) | 2295 | 392 | 2.8 | 1.2 (1.1 to 1. 3) | 1.1 (1.0 to 1.3) | 1.1 (1.0 to 1.2) |
| Quartiles | ||||||
| <196 | 577 | 85 | 2.4 | 1.0 (ref) | 1.0 (ref) | 1.0 (ref) |
| 196–267 | 571 | 83 | 2.4 | 1.0 (0.7 to 1.3) | 0.9 (0.7 to 1.2) | 0.9 (0.7 to 1.2) |
| 268–357 | 593 | 107 | 2.9 | 1.2 (0.9 to 1.6) | 1.2 (0.9 to 1.6) | 1.1 (0.8 to 1.4) |
| >357 | 554 | 117 | 3.5 | 1.5 (1.1 to 1.9) | 1.3 (1.0 to 1.8) | 1.2 (0.9 to 1.6) |
| Visceral fat | ||||||
| Continuous (per SD=67) | 2295 | 392 | 2.8 | 1. 4 (1.3 to 1.5) | 1.2 (1.1 to 1.4) | 1.2 (1.1 to 1.3) |
| Quartiles | ||||||
| <94 | 584 | 65 | 1.8 | 1.0 (ref) | 1.0 (ref) | 1.0 (ref) |
| 94–132 | 591 | 89 | 2.3 | 1.3 (1.0 to 1.8) | 1.2 (0.8 to 1.5) | 1.1 (0.8 to 1.4) |
| 133–181 | 572 | 103 | 2.9 | 1.6 (1.2 to 2.2) | 1.2 (0.9 to 1.7) | 1.2 (0.9 to 1.5) |
| >181 | 548 | 135 | 4.2 | 2.3 (1.7 to 3.1) | 1.6 (1.1 to 2.2) | 1.5 (1.1 to 2.0) |
| R thigh intermuscular fat area, cm2 | ||||||
| Continuous (per SD=6.8) | 2288 | 388 | 2.8 | 1.2 (1.1 to 1.3) | 1.1 (1.1 to 1.3) | 1.1 (1.0 to 1.2) |
| Quartiles | ||||||
| <6.15 | 599 | 69 | 1.8 | 1.0 (ref) | 1.0 (ref) | 1.0 (ref) |
| 6.15–9.01 | 605 | 95 | 2.5 | 1.4 (1.0 to 1.9) | 1.2 (0.9 to 1.6) | 1.2 (0.9 to 1.6) |
| 9.02–13.12 | 567 | 117 | 3.4 | 1.9 (1.4 to 2.5) | 1.5 (1.1 to 1.9) | 1.4 (1.1 to 1.9) |
| >13.12 | 517 | 107 | 3.6 | 2.0 (1.5 to 2.7) | 1.5 (1.1 to 2.0) | 1.4 (1.1 to 1.9) |
| Waist circumference | ||||||
| Continuous (per SD=12.5) | 2294 | 392 | 2.8 | 1.3 (1.2 to 1.4) | 1.2 (1.1 to 1.3) | 1.2 (1.1 to 1.3) |
| Quartiles | ||||||
| <91.7 | 582 | 69 | 1.9 | 1.0 (ref) | 1.0 (ref) | 1.0 (ref) |
| 91.7–99.2 | 597 | 89 | 2.4 | 1.3 (0.9 to 1.7) | 1.2 (0.9 to 1.7) | 1.2 (0.9 to 1.6) |
| 99.3–107.1 | 586 | 110 | 3.1 | 1.6 (1.2 to 2.2) | 1.3 (1.0 to 1.7) | 1.2 (0.9 to 1.7) |
| >107.1 | 529 | 124 | 4.0 | 2.1 (1.6 to 2.8) | 1.6 (1.2 to 2.1) | 1.4 (1.1 to 1.9) |
| BMI | ||||||
| Continuous (per SD=4.6) | 2295 | 392 | 2.8 | 1.2 (1.2 to 1.4) | 1.2 (1.1 to 1.3) | 1.2 (1.0 to 1.3) |
| Quartiles | ||||||
| <24.1 | 575 | 71 | 2.0 | 1.0 (ref) | 1.0 (ref) | 1.0 (ref) |
| 24.1–26.8 | 607 | 91 | 2.4 | 1.2 (0.9 to 1.6) | 1.1 (0.8 to 1.5) | 1.1 (0.8 to 1.4) |
| 26.9–30.0 | 580 | 102 | 2.8 | 1.4 (1.1 to 1.9) | 1.1 (0.9 to 1.5) | 1.1 (0.8 to 1.5) |
| >30.1 | 533 | 128 | 4.1 | 2.0 (1.5 to 2.7) | 1.6 (1.2 to 2.1) | 1.4 (1.1 to 1.9) |
Incident CKD was defined as a follow-up eGFRcysC≤60 ml/min per 1.73 m2 in individuals with baseline GFR>60 ml/min per 1.73 m2. Inc, incident; IRR, incident rate ratio; 95% CI, 95% confidence interval; ref, reference; R, right; BMI, body mass index.
a
Adjusted for age, sex, race, site, and baseline eGFR.
b
Further adjusted for diabetes mellitus, systolic blood pressure, hypertension meds, albumin-to-creatinine ratio, smoking, LDL cholesterol, HDL cholesterol, oral estrogen, prevalent coronary heart disease, and prevalent heart failure.