Table 3.
Metastatic Disease in Pediatric and Adult Patients With PPGLs
| Characteristics | Pediatric | Adult | P Value |
|---|---|---|---|
| Metastatic diseasea | |||
| Synchronousa | 25.5% (12/47) | 43.2% (82/190) | 0.0019 |
| Nonsynchronousa | 74.5% (35/47) | 56.8% (108/190) | |
| Location of metastases | |||
| Bones | 73.9% (34/46) | 69.9% (128/183) | 0.3690 |
| Lungs | 39.1% (18/46) | 25.7% (47/183) | 0.0540 |
| Liver | 23.9% (11/46) | 40.9% (75/183) | 0.0230 |
| Lymph nodes | 50.0% (23/46) | 45.6% (84/184) | 0.3690 |
a
Metastatic disease is defined as either synchronous or nonsynchronous depending on findings of metastases (lungs, liver, bones, lymph nodes, or other sites where chromaffin or autonomic progenitors are normally absent) at the time of first diagnosis of disease or at one or more years after first diagnosis, respectively.