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. 2016 Dec 8;24(5):492–504. doi: 10.1177/2047487316682186

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© The European Society of Cardiology 2016

This article is distributed under the terms of the Creative Commons Attribution 4.0 License (http://www.creativecommons.org/licenses/by/4.0/) which permits any use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 3. — Association of Lp-PLA₂-lowering alleles with Lp-PLA₂ activity and CHD risk. Spectrum of functional alleles in PLA2G7 and effects on Lp-PLA2 activity (red estimates) and coronary heart disease risk (black estimates); *Carriage of any of the four loss-of-function variants c.109+2T>C, Arg82His, Val279Phe, Gln287Ter. ^†One study did not provide tabular data to enable calculation of CHD odds ratios in heterozygotes or homozygotes. Hence, numbers are less than those presented for the per allele analysis in Table 2. CHD: coronary heart disease; CI: confidence interval; LoF: loss-of-function; Lp-PLA₂: lipoprotein associated phospholipase A₂.