Table 5.
Top 10 Canonical Pathways Regulated by E2B in WT, KIKO, and ERKO Females
|
Top Canonical Pathways |
P Value |
Genes |
|---|---|---|
| WT | ||
| Intrinsic prothrombin activation pathway | 0.0002 | Col1a1, Col2a1, Col3a1 |
| Dendritic cell maturation | 0.0004 | Col1a1, Col2a1, Hla-Dqa1, Tnfrsf11b, Col3a1 |
| Thyroid cancer signaling | 0.0005 | Myc, Cdh1, Bdnf |
| Hepatic fibrosis/hepatic stellate cell activation | 0.0008 | Col1a1, Igfbp3, Col2a1, Tnfrsf11b, Col3a1 |
| Neuroprotective role of THOP1 in Alzheimer disease | 0.0091 | Pdyn, Nts |
| Atherosclerosis signaling | 0.0107 | Col1a1, Col2a1, Col3a1 |
| Endometrial cancer signaling | 0.0195 | Myc, Cdh1 |
| T helper cell differentiation | 0.0302 | Hla-Dqa1, Tnfrsf11b |
| Wnt/β-catenin signaling | 0.0309 | Myc, Cdh1, Sox3 |
| PDGF signaling | 0.0398 | Myc, Sphk1 |
| KIKO | ||
| Prostanoid biosynthesis | 0.004 | Ptgds |
| Role of JAK1, JAK2, and TYK2 in interferon signaling | 0.0091 | Cga |
| Autoimmune thyroid disease signaling | 0.0158 | Cga |
| Nicotine degradation II | 0.0234 | Inmt |
| Glutamate receptor signaling | 0.0245 | Slc17a7 |
| Eicosanoid signaling | 0.0263 | Ptgds |
| Role of BRCA1 in DNA damage response | 0.0339 | Pou2f1 |
| Protein kinase Cθ signaling in T lymphocytes | 0.0479 | Pou2f1 |
| Ovarian cancer signaling | 0.055 | Cga |
| Glucocorticoid receptor signaling | 0.1102 | Pou2f1 |
| ERKO | ||
| Oxidative phosphorylation | 0.0003 | Uqcrq, Ndufb10, Atp5e |
| Circadian rhythm signaling | 0.0009 | Avp, Vip |
| Mitochondrial dysfunction | 0.0013 | Uqcrq, Ndufb10, Atp5e |
| EIF2 signaling | 0.0015 | Rpl36a, Rpl41, Rps24 |
| Retinoic acid–mediated apoptosis signaling | 0.0603 | Tnfsf10 |
| nNOS signaling in neurons | 0.0603 | Capn11 |
| Amyloid processing | 0.0661 | Capn11 |
| Regulation of cellular mechanics by calpain protease | 0.0724 | Capn11 |
| Eicosanoid signaling | 0.0813 | Alox5p |
| GPCR-mediated integration of enteroendocrine signaling exemplified by an L cell | 0.0891 | Vip |
Top 10 canonical pathways as analyzed using IPA. Genes listed following each canonical pathway represent either an increase or decrease in gene expression.
Abbreviations: nNOS, neuronal nitric oxide synthase; PDGF, platelet-derived growth factor; GPCR, G protein–coupled receptor.