Figure 5.

Subfertility of Pgrmc2^d/d mice is uterine in origin. (A) There was no significant difference between Pgrmc2^fl/fl and Pgrmc2^d/d females in the number of implantation sites at DOP10.5 (n = 6 to 7). (B) There was a sevenfold increase in postimplantation embryonic death in Pgrmc2^d/d females compared with Pgrmc2^fl/fl females on DOP10.5. *P < 0.05. (C) Representative images of uteri from DOP10.5 Pgrmc2^fl/fl and Pgrmc2^d/d showing resorption sites, as indicated by black arrows. Picric acid stain showing histology of representative (D) DOP10.5 and (E) DOP7.5 implantation sites from Pgrmc2^fl/fl and Pgrmc2^d/d mice.