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. 2017 Jan 23;158(4):903–919. doi: 10.1210/en.2016-1576

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Copyright © 2017 Endocrine Society

This article has been published under the terms of the Creative Commons Attribution License (CC BY; https://creativecommons.org/licenses/by/4.0/).

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Figure 3. — Insulin effect on Nrf2, Agt, hnRNP F, and hnRNP K gene promoter activity in IRPTCs. Cells stably transfected with (a) pGL4.20-Nrf2, (b) pGL4.20-Agt, (c) pGL4.20-hnRNP F, or (d) pGL4.20-hnRNP K gene promoter were incubated in NG or HG DMEM ± insulin for 24 hours with or without wortmannin, Ly-294, 002, PD98059, or U0126 or transiently transfected with p42 MAPK or p44 MAPK siRNA (e–h). Luciferase activity in cells cultured in NG medium was considered as 100%. The results are expressed as percentage of control (mean ± SEM, n = 3). *P < 0.05; **P < 0.01; ***P < 0.005. Similar results were obtained in two separate experiments. NS, not significant; RLU, relative luciferase unit.