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. 2017 Jan 13;158(4):815–830. doi: 10.1210/en.2016-1788

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Figure 3. — TSH synthesis is reduced in Igsf1^Δ312/y mice. Serum (a) TSH, (b) T4, (c) T3 levels, and (d) pituitary TSH content in 8-week-old wild-type and Igsf1^Δ312/y males. (e) Number of thyrotrope cells counted per unit area on immunohistochemistry-stained sections. (f–h) Tshb, Cga, and Trhr1 mRNA levels in pituitaries of 10-week-old wild-type and Igsf1^Δ312/y males. The data were analyzed by a two-tailed unpaired t test: (a) t = 0.7735, df = 20.40, N.S. P = 0.4481; (b) t = 0.3515, df = 22.00, N.S. P = 0.7285; (c) t = 0.4876, df = 20.88, N.S. P = 0.6309; (d) t = 4.645, df = 21.78, ***P = 0.0001; (e) t = 0.5445, df = 9.263, N.S. P = 0.5990; (f) t = 5.316, df = 15.68, ****P < 0.0001; (g) t = 2.644, df = 23.04, *P = 0.0145; (h) t = 4.353, df = 17.82, ***P = 0.0004. N.S., not significant.