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. 2017 Jan 24;158(4):920–935. doi: 10.1210/en.2016-1538

Figure 9.

Figure 9.

Effect of DSM (an inhibitor of Alk2, 3, and 6) on DHT-stimulated follicle growth in vitro for 72 hours. (a) TGFβ receptor inhibition by DSM. (b) Isolated follicle growth in the presence and absence of DHT and/or DSM. Relative area of follicles in different treatments was compared at each time point using one-way ANOVA with a Tukey’s multiple comparisons test. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 00001. Values are mean and 95% confidence interval. Numbers in parentheses are numbers of follicles. (c–f) Effect of DHT alone, DSM alone, and DHT in combination with DSM on gene expression following 72 hours of culture. Data have been log2 transformed, and DHT, DSM, or DHT plus DSM treatment was compared with control samples (0) using an unpaired t test. Fold change is indicated in right-hand y axis. Asterisks by error bars indicate significant difference in expression from control, and differences between treatments are indicated by asterisks on horizontal lines. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 00001. Values are mean and SEM. (c) TGFβ ligands. (d) Hormone receptors. (e) TGFβ receptors. (f) Steroidogenic enzymes.