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. 2017 Jan 23;158(5):1130–1139. doi: 10.1210/en.2016-1451

Figure 3.

Figure 3.

Effects of PTH injection in ADHR mice or in animals pretreated with the furin inhibitor 537076 (at concentration 7.5 μg/g) or PBS vehicle. (a) cFGF23 and (b) iFGF23 changes after PTH injection (50 nmol/kg), or vehicle (10 mm citric acid, 150 mm NaCl, 0.05% Tween 80, pH 5.0) in ADHR mutant mice. n = 6–8 per group. Baseline cFGF23 levels in ADHR mutant mice in different experiments ranged between 190 ± 13 and 281 ± 19 pg/mL, and peak cFGF23 levels ranged between 485 ± 78 and 1242 ± 239 pg/mL, whereas baseline iFGF23 levels in ADHR mutant mice in different experiments ranged between 262 ± 23 and 345±18 pg/mL, and peak iFGF23 levels ranged between 450 ± 25 and 975 ± 149 pg/mL. Changes in cFGF23 and iFGF23 levels are reported as percentage of change from baseline. (c) cFGF23 and (d) iFGF23 levels in WT mice all injected with PTH; furin refers to mice pretreated with furin inhibitor, and vehicle refers to mice pretreated with vehicle as described. n > 4 mice per group. *P < 0.05. Hashed line shows 100% of baseline.