Figure 6.

Exercise and WBV enhance cortical BMD in db/db mice. (a) Three months of daily TE increased BMD at the femoral neck in db/db mice. (b) The effects of genotype were regionally differentiated along the length of the femur, as BMD at the femoral middiaphysis was similar between WT and db/db mice. (c) Biomechanical analysis of ultimate load (F.Max) in the radius revealed reductions in bone strength in db/db mice. (d) There were no effects of genotype or musculoskeletal loading on stiffness (N/mm) following biomechanical testing in the radius. For graphs, bars represent the average of (n = 6 to 8) mice in the indicated conditions, and hashtags denote the effect of genotype following 2 × 3 ANOVA with statistical significance at P < 0.05. Asterisks indicate significant differences relative to matched-genotype SED mice following one-way ANOVA with Bonferroni-corrected post hoc comparisons.