Fig 3. Basal and insulin-stimulated glucose incorporation into skeletal muscle glycogen (glycogenesis) and into lipids in epididymal fat (lipogenesis) in SHR and SHR-CRP rats treated with placebo or with salsalate.

SHR-CRP rats treated with salsalate showed significantly increased sensitivity of skeletal muscle to insulin action when compared to nontransgenic SHR. No significant treatment effects were observed for basal- or insulin-stimulated lipogenesis. * denotes significant differences (P<0.05) between placebo versus salsalate-treated groups; † denotes significant strain x treatment interactions, i.e. salsalate treatment protects against the adverse effects of human CRP.