Table 3. List of genes from KEGG pathways identified by SPIA showing the effects of salsalate versus placebo in SHR controls (A) and in SHR-CRP rats (B).

A. Effects of salsalate vs. placebo in SHR controls	FWER	Deregulated genes (P<0.05)
PPAR signalling	2.15e-06	↑Ehhadh, ↑Acaa1a, ↑Acaa1b, ↑Fads2, ↓Cyp4a8, ↑Cyp4a1, ↑Acsl1, ↓Apoa5, ↑Acadl, ↑Me1, ↑Acsl4, ↑Slc27a2, ↑Fabp1, ↑Acadm, ↑Acox1, ↑Scd, ↑Dbi, ↑Fabp7, ↑Ppara, ↑Cpt2, ↓Mmp1, ↑Cyp27a1, ↑Scd1
Circadian rhythms	0.0014	↓Arnlt, ↑Per3, ↑Cry2, ↑Per1, ↑Skp1, ↓Npas2, ↑Per2, ↑Prkag2, ↑Prkaa1, ↓Prkab1
B. Effects of salsalate vs. placebo in SHR-CRP rats	FWER	Deregulated genes (P<0.05)
PPAR signalling	1.49e-05	↑Acaa1b, ↑Ehhadh, ↑Acaa1a, ↑Cpt2, ↑Acox1, ↑Acadl, ↓Fabp2, ↑Cyp4a1, ↓Apoa5, ↑RGD1565355 (similar to Cd36), ↑Hmgcs2, ↑Slc27a2, ↑Acadm, ↓Ppard, ↑Scd1, ↑Fabp1, ↑Fabp7, ↓Cyp4a8, ↑Ppara, ↑Acsbg1, ↑Pck1, ↑Acsl4, ↑Pltp, ↑Fads2
Circadian rhythms	5.49e-05	↑Cry1, ↓Npas2, ↑Per2, ↓Prkab1, ↑Per3, ↑Per1, ↑Cry2
Protein processing in the endoplasmic reticulum	0.0036	↑Hsph1, ↑Hspa8, ↑Hsp90ab1, ↑Ddit3, ↑Dnaja1, ↓Uggt1, ↓Calr, ↑Sec23b, ↓Pdia6, ↓Pdia3, ↑Herpud1, ↓Xbp1, ↓P4hb, ↓Rpn1, ↑Ufd1l, ↓Dnajc3, ↓Hsp90b1, ↓Stt3b, ↑Plaa, ↓Dnajb11, ↑Hspa4l, ↑Dnajb2, ↑Eif2s1, ↑Vimp, ↓Sel1l, ↓Sec61b, ↓Derl3, ↓Os9, ↓Ddost, ↓Pdia4, ↓Fbxo6, ↓Tram1, ↑Nploc4, ↑Hspa2, ↓Mapk9, ↑Traf2

↑ and ↓ denote up- and downregulated, respectively, in salsalate- versus placebo-treated rats. FWER–Family-Wise Error Rate