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. 2011 Oct;45(4):858–866. doi: 10.1165/rcmb.2010-0401OC

Figure 5.

Figure 5.

(a) Granulomatous foci are associated with an up-regulation in matrix proteases and a down-regulation of tissue inhibitor of metalloproteinases (TIMP)–3. The mRNA gene expression of MMPs and TIMP-3 was obtained from a PCR gene array of lung tissue via LCM from sham untreated mice, unaffected lung tissue [Granuloma (−)], and granulomatous foci [Granuloma (+)]. (b) Integrins (Itgs) are elevated within granulomatous foci at 60 and 90 days after exposure to MWCNTs. The mRNA gene expression of integrins was obtained from a PCR gene array of lung tissue obtained via LCM from sham untreated mice, unaffected lung [Granuloma (−)], and granulomatous foci [Granuloma (+)]. Itgs are elevated within granulomatous foci at 60 and 90 days after exposure to MWCNTs.