TABLE 2.
MRNA FOLD CHANGE OF SELECTED CYTOKINES FROM LUNG GRANULOMA TISSUE OBTAINED WITH LCM, COMPARED WITH LUNG TISSUE OF CONTROL MICE
| Cytokine Profile of mRNA Fold Change
in LCM Granulomas | |||
| Th1 | Gene | 60 Days | 90 Days |
| TNFRSF1b | 3* | 2 | |
| TNF-α | 2 | 8* | |
| IL-18 | 2* | 5* | |
| Th2 | CCL7 (MCP-3) | 7* | 6* |
| CCL11 (eotaxin) | 7* | Unchanged | |
| IL-10 | 5 | 10* | |
| Other chemokines | CCL2 (MCP-1) | 6* | 16* |
| CCL22 (SCYA2) | 6* | 5* | |
| CCL20 (MIP-3α) | 27* | 92* | |
| CCL9 (MIP-1γ) | 3* | 8* | |
Definition of abbreviations: CCL, chemokine (C-C motif) ligand; LCM, laser-capture microdissection; MCP, monocyte chemotactic protein; MIP, macrophage inflammatory protein; SYCA2, small inducible cytokine A2; TNFRSF1b, tumor necrosis factor receptor superfamily member 1B.
*
P < 0.05.