Figure 1.

Dose-dependent effect of paraquat (PQ) on acute lung injury (ALI). Mice were injected intraperitoneally with normal saline (N) or saline-diluted PQ solution at a dose of 10 mg/kg (PQ10), 20 mg/kg (PQ20), or 50 mg/kg (PQ50), and mice were killed for analysis 48 hours later. Weight loss (A), relative lung weight (B), bronchoalveolar lavage fluid (BALF) total protein (C), and myeloperoxidase (MPO) activity (D) were analyzed. *P < 0.05, **P < 0.01 between 0 and 48 hours after PQ injection (A), or between the PQ injection groups and the normal control group (B–D). Data presented are means (±SD); n = 8 per group.