Figure 10.

miR-21 downregulation exacerbated ALDO/SALT-mediated cardiac dysfunction. Rats were treated with ALDO/SALT (A/S) or vehicle for 2 weeks. miR-21 antagomir (Antag) was administered starting on day 5 for 3 consecutive days. (a) Cardiac output (CO) and (b) fractional shortening (FS) were measured by echocardiography. Each determination is the mean of 12 to 15 cardiac cycles derived from three separate M-mode images during each session. Results are expressed as mean ± standard error of the mean (n = 5). *P < 0.05 versus control (Crtl); #P < 0.05 versus A/S.