Figure 7.

miR-21 downregulation exacerbated ALDO/SALT-mediated cardiac interstitial and perivascular fibrosis and scar formation. Rats were treated with ALDO/SALT (A/S) or vehicle for 2 weeks. miR-21 antagomir (Antag) was administered starting on day 5 for 3 consecutive days. (a) Interstitial and (b) perivascular fibrosis and (c) scars were quantified in trichrome-Masson–stained cardiac sections. Results are expressed as mean ± standard error of the mean (n = 5). *P < 0.05 versus control (Ctrl); #P < 0.05 versus A/S.