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Potential Upstream Regulators Predicted to Cause Changes in DKO Epidermisa
| Activation z Score | P Value of Overlap | |
|---|---|---|
| 1,25D3 | 1.783 | 1.81E–10 |
| CTNNB1 | –2.336 | 4.08E–08 |
| MYC | –2.645 | 2.38E–11 |
Genome-wide microarray profiling revealed differentially expressed genes caused by deletion of Vdr and Casr. IPA pathway analysis predicted potential upstream regulators that would cause these changes (with statistical significance), among which Vdr ligand (1,25(OH)2D3) is listed.
